The targeting construct contains (from 5' to 3'): a CAG promoter, loxP-STOP-loxP (LSL), a 3X FLAG epitope, Ormdl3 cDNA, polyA sequence flanked by ROSA26 5' and 3' homology arms and inserted into the Gt(ROSA)26Sor locus. Cre-mediated recombination removed the LSL sequence. (J:341336)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count