Drd2^em1Knev

Guide RNA [GACCCGCUUCCGACGCUUG] is used to insert an isoleucine to phenylalanine substitution at position 212 (c.634 A to T) in exon 5. Drd2 transcript Drd2-201 (ENSMUST00000075764.8) was utilized as reference for the exon number and guide sequences. In humans, the I212F mutation is associated with progressive chorea and cervical dystonia. (J:343841)