Otof^em3Bros

This mouse line was generated by site-directed CRISPR-Cas9 mutagenesis in C57BL/6NCrl mice causing a D1821A/D1822A mutation (Corresponds to D1841A/D1842A mutation in the isoform e peptide coded for by the human ortholog). Additional silent mutations were introduced. The mutated exon38 now reads:(5')gtggctgaagggccagcaggaggacaaacaggacacagatgtccactatcactccctcacgggggagggcaacttcaactggagatacctcttccccttcgactacctagcggccgaagagaagatcgttatgtccaaaaaggagtctatgttctcctgggatgagacggagtacaagatccctgcgcggctcaccctgcagatctgggacgctgaTcacttctcggctgCTgCcttcctgg (3') (J:344236)