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The transgene contains a bi-directional tetracycline-responsive promoter element controlling the expression of the nuclear-localized beta-galactosidase (nLacZ) on one side and fusion transcript composed of green fluorescent protein variant (Venus), fused via the ribosomal skipping sequence T2A to the brain-specific isoform (A) of the human gene with the mutation responsible for the amino acid substitution of arginine with a stop codon at position 462 (R462*). (J:310967)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
