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The coding sequence was inverted and flanked with a pair of loxP sites and a pair of lox2722 sites via homologous recombination. Decreased expression in hemizygous and homozygous mice was confirmed by qRT-PCR. Expression of Clnc5 or the four nearby miRNAs was not reduced. Cre-mediated recombination will invert the coding sequence and restore expression. (J:343467)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
