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Serine codons 86 in exon 3 (TCC) and 274 (AGT) and 421 (TCA) in exon 4, and threonine codon 308 (ACC) in exon 4 were changed to alanine (GCT, GCT, GCA, GCC) (p.S86A, p.S274A, p.S421A, p.T308A) and a loxP site flanked neomycin resistance gene cassette was inserted into intron 3. The neo cassette was removed through subsequent Cre-mediated recombination. The mutations prevent activity-induced phosphorylation of the affected residues in the encoded peptide. (J:342941)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
