Apoe^{em1(APOE_i4*)Yhg}

CRISPR/Cas9 technology introduced a C to A change resulting in an arginine to serine substitution at amino acid 136 (p.R136S) in the inserted human APOE isoform 4 of the Apoetm3(APOE_i4)Yhg allele. (J:343279)