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The targeting vector is designed to insert a 343 kb (Chr21:25880264 - 26224036) fragment of the human APP (apolipoprotein) in place of 268 kb (Chr16:84750107 - 85019011) of the mouse App gene. The construct includes an FRT-flanked neomycin selection cassette. In addition, there is also a APP-DT (non-coding antisense RNA) in the human genome segment. The insertion disrupts App transcription.The neomycin cassette was removed by transient expression of cre. (J:101977)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
