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CRISPR/Cas9 endonuclease-mediated genome editing is used to create a 12 base pair deletion in exon 4. The mutation removes the KRKR coding sequence. Two guide RNAs (5'-ccagcctcaggaagcg gaaa-3'; 5'-cggaatccagcctcaggaag-3'), cas9 endonuclease and a 120-nucleotide (nt) repair template are used. The deletion disrupts binding of heparin sulfate but does not affect IFNGR binding. (J:335280)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
