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Leucine codon 359 (TTA) in exon 5 was changed to valine (GTA) (p.L359V) and a loxP site flanked neomycin resistance gene was inserted into an intron. The mutation is the equivalent of the same human mutation associated with acute myeloid leukemia (AML) and myelomonocytic transformation of chronic myelogenous leukemia (CML). (J:342777)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
