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CRISPR/cas9 endonuclease-mediated genome editing is used to delete exons 2-7 using sgRNA (CCCCTCCGCCAGCCTATAGCTTC,TAGGGCATTAGAGCCACTCGGG and ATATTATGGTGGCTTAGGGTAGG, CCCTCTCACATGCACGATTCACT). The 1537 bp [bps 41755833 to 41757369, using GRCm39 (NC_000070.7)] deletion includes exons 2-7, and parts of introns 1 and 7 including the nucleotides coding for the enzyme's His-Pro-His active site. (J:101977)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
