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The targeting construct inserted after the STOP codon in the last exon (24) a loxP site, IRES sequence, lacZ reporter gene, neomycin resistance cassette and loxP site. Exon 22 was modified by nucleotide substitutions to accomplish the amino acid substitution of alanine for aspartic acid at position 931 (D931A). (J:228659)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
