Log In|Sign Up
EN
CRISPR/cas9 endonuclease-mediated genome editing is used to create an amino acid substitution at position 186 altering threonine to serine (T186S; ACT to TCG) with two silent mutations (I185I, ATA to ATT, and L191L, CTT to TTA) in exon 6. The mutation is homologous to human T185S and is associated with frontotemporal lobar degeneration. (J:343012)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
