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Two stop codons were introduced to the beginning of short consensus repeat domain 19 (SCR19) generating a TCAACA to TAATGA change in exon 19. An FRT site, neomycin selection cassette, loxP site and second FRT site were inserted upstream of exon 19. Homozygous mice show low levels of Cfh RNA in the liver and only a small amount of truncated protein is detected in the plasma. (J:264171)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
