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Cysteine codons 1235 (TGT) and 1260 (TGC) in exon 26 were changed to serine (AGT, AGC) (p.C1235S, p.C1260S) and a loxP site flanked neomycin resistance gene cassette was inserted into intron 25. The neo cassette was removed through subsequent Cre-mediated recombination. The mutations, in the TGFB-binding 8-cysteine domain of the encoded peptide, blocks TGFB binding. (J:279186)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
