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CRISPR/Cas9 technology generated an 8-bp deletion leading to a frameshift that prolongs the mutant protein by 23 amino acids changing the phenylalanine at position 600 to a leucine (G601QfsTer34). This deletion was generated by simultaneously injecting C57BL/6N zygotes with two sgRNAs targeting Birc2 (5-TCTGCAGGGGGACAATCAAG-3) and Birc3 (5-ATCTGTAGAGGGACCATCAA-3) and was generated at the same time as the Birc2em1Haka allele. (J:342656)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
