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A beta-actin promoter and loxP-flanked TK-Neo STOP cassette followed by the Polb gene containing a leucine to proline substitution at amino acid 22 (p.L22P, CTC to CCC) were inserted into the locus. This mutation results in loss of 5-deoxyribose-5-phosphate lyase activity and inefficient base excision repair. The p.L22P variant is associated with gastric cancer in humans. This line is generated from ES clone 89. (J:340207)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
