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Tryptophan codon 807 (TGG) in exon 17 was targeted for change to arginine (AGG) (p.W807R) using an sgRNA (targeting TCTCAGCCACCCATGGTTAC) and an ssODN template with CRISPR/Cas9 technology. This allele represents an unintended 7 bp deletion (TACAGGT) of the last 5 bp of exon 17 and the first 2 bp of intron 17, which includes nucleotides from the last two codons of exon 17 (L and Q codons) and the core splice donor site. (J:296761)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
