This allele was generated at The Jackson Laboratory by electroporating Cas9 protein and 2 guide sequences ACTCTCTCTTGAATTCCTGG and GATTCATACTCTCCACAAAC, which resulted in a 599 bp deletion beginning at Chromosome 17 position 37,260,665 bp and ending after 37,261,263 bp (GRCm39/mm39). This mutation deletes ENSMUSE00000267860 (exon 2) and 490 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 28 and early stop 83 amino acids later. (J:188991)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count