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EN
Arginine 264 (CGA) in exon 5 was changed to alanine (GCA) and a loxP site flanked neomycin resistance gene cassette was inserted into intron 5. The neo cassette was removed through subsequent Cre-mediated recombination. The mutation abrogates the rapid dilation of mesenteric arteries and the acceleration of endothelial repair of carotid actions of the encoded peptide without affecting other functions. (J:302599)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
