A loxP site was inserted into intron 1 and an FRT-flanked neomycin cassette and second loxP site were inserted downstream of exon 3. The neomycin cassette was removed via flp-mediated recombination, leaving exon 2, 3, and the 3 UTR floxed. (J:342291)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count