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A mutated mouse Mybpc3 cDNA is expressed under the control of a mouse alpha-MHC promoter. The Mybpc3 phosphorylation sites (Ser-273, Ser-282, Ser-302), along with two adjacent sites that could be potentially phosphorylated (Thr-272, Thr-281) were converted to alanine, and a sequence encoding the myc epitope was added to the construct. Lines 45, 262 and 272 were generated, but line 262 was selected for further study. (J:117505)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
