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A loxP-flanked stop cassette (LSL) and Akt1 cDNA containing a glutamic acid to lysine substitution at amino acid 17 (p.E17K) with an N-terminal Flag tag were inserted into the locus. The pE17K mutation renders constitutive activation of AKT1. Cre mediated recombination is required to induce expression of the constitutively active AKT1. (J:298712)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
