CRISPR/Cas9 technology using gRNAs 5-AAAAGATGAAATTGAAGAGA-3 for the second exon and 5-ATTTATGACAGCGATAGCTC-3 for the sixth exon, generated a 12,565-bp deletion of exons 2-6. Western blot analysis confirmed absence of protein in testicular germ cells of homozygotes. (J:338084)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count