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EN
Alanine codon 393 (GCT) in exon 7 was changed to threonine (ACT) (p.A393T) and an FRT site flanked neomycin resistance gene cassette was inserted into intron 8. The neo cassette was removed through subsequent Flp-mediated recombination. The mutation is the equivalent of the human p.A391T mutation (SNP rs13107325) associated with numerous traits, including reduced arterial blood pressure, increased body mass index and hyperlipidemia. (J:341571)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
