A loxP site was inserted upstream of exon 3 and an FRT-flanked PGK-neomycin cassette and second loxP site were inserted downstream of exon 3 via CRISRP/Cas9 technology. Flp-mediated recombination removed the selection cassette and left exon 3 floxed. (J:314515)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count