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The Cre expression cassette including the stop codon was inserted into the BAC clone RP23-182D4 containing the endogenous murine Ccr2 locus downstream of the Ccr2 promoter. The endogenous Ccr2 gene was disrupted resulting in frameshift. Four potential founder mice were identified. The lineage of one of these founders (#584) was established. (J:341212)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
