An IRES-Cre was introduced between the coding sequence of exon 6 and the 3'UTR of the Ucp1 gene. To avoid disrupting the polyA signal of Ucp1 expression, a Neo cassette flanked by frt sites was inserted 300 bp downstream of the 3'UTR. (J:283206)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count