A loxP site, an FRT site, a neomycin resistance gene cassette and a second FRT site were inserted into intron 2 and a second loxP site into intron 3. The neo cassette was removed through subsequent Flp-mediated recombination, leaving exon 3 floxed. (J:303080)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count