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The targeting vector was designed to insert an FRT-flanked neomycin resistance (neo) cassette and a loxP site upstream of exon 2. A second loxP site was inserted downstream of a mutated exon 3. Exon 3 was altered to contain three amino acid substitutions: proline to leucine (P64L), lysine to glutamate (K72E), and isoleucine to histidine (I73H) to obtain the murine orthologue of human CXCL4L1. Flp-mediated recombination removed the neo cassette. (J:270132)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
