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Aspartic acid codon 298 (GAT) in exon 3 was changed to glycine (GGT) (p.298G) and asparagine codon 397 (AAC) in exon 3 to isoleucine (ATC) (p.N397I) using sgRNAs and ssODN templates with CRISPR/Cas9 technology. The mutations replicate the human p.D299G (c.896A>G, rs4986790) and p.T399I (c.1196C>T, rs4986791) mutations associated with LPS hyporesponsiveness and differential susceptibility to many infectious and non-infectious diseases. (J:303648)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
