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A loxP site, a minigene consisting of the cDNA sequence for exons 11-17, a STOP cassette, a neomycin resistance gene cassette and a second loxP site were inserted into intron 10 and endogenous exon 11 was modified to change lysine codon 375 (AAG) to methionine (ATG) (p.K375M). This allele expresses the wildtype transcript and only after Cre-mediated deletion of the minigene-STOP-neo cassette will it express the mutated transcript. The mutation renders the encoded protein kinase-dead. (J:303935)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
