Log In|Sign Up
EN
Arginine codon 186 (CGA) in exon 6 was changed to tryptophan (TGG) (p.R186W) using crRNA, tracrRNA and an ssODN template with CRISPR/Cas9 technology. The mutation affects mechanoelectrical transduction (MET) by cochlear hair cells and causes deafness. (J:307668)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
