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Tyrosine codon 138 (TAT) in exon 5 was changed to leucine (TTG) (p.Y138L) and an FRT site flanked puromycin resistance gene cassette was inserted into intron 4. The puro cassette was removed through subsequent Flp-mediated recombination. The mutation leads to the encoded protein lacking protein phosphatase activity while leaving lipid phosphatase activity intact. (J:330701)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
