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Exon 18 was targeted with an sgRNA (targeting GGTCCTCTTCGCTTAAATACTAG) using CRISPR/Cas9 technology, resulting in a 7 bp deletion (GAAGCGA) that leads to a frameshift and premature stop codon (NM_026789.5:c.2865-2871del, p.K956Ffs*4). This mutation essentially mimics the human c.2872C>T (p.R958*) mutation associated with male infertility. (J:333969)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
