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The murine Fabp4 sequence was humanized by introducing point mutations to convert the 11 amino acids in exons 2 and 3 that differ between mouse and human FABP4 to human FABP4 sequences. A loxP site was inserted within intron 1 upstream of exon 2 and a FRT-neomycin-FRT-loxP cassette was inserted at the 3 end of exon 2. Resulted chimera were crossed to Flp recombinaseexpressing mice to excise neomycin selection cassette. (J:339978)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
