A loxP site was inserted upstream of exon 4 and a floxed neo cassette followed by an IRES-EGFP replaces the non-coding portion of exon 4. Cre-mediated recombination removed the selection cassette. (J:92262)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count