The targeting vector is designed to insert a loxP-flanked neomycin resistance (neo) cassette upstream of the exon 1, and a single loxP site downstream of exon 1. Cre-mediated recombination removed the neomycin cassette leaving exon 1 floxed. (J:75115)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count