A pair of guide-RNAs (gRNAs) are used to introduce loxP sites to intron 1 and intron 3. Cre-mediated recombination removed exons 2-3. (J:338970)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count