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EN
Lysine codon 298 in exon 8 (ENSMUST00000106609) or 9 (ENSMUST00000029483) was targeted for change to alanine using an sgRNA (targeting TTGGTTGGTTCCACCAACAAAGG ) and an ssODN template with CRISPR/Cas9 technology. This allele is the result of incorrect repair, with the insertion or duplication of a C five nucleotides from the 3' end of the exon (GRCm39:chr3:108580229dup), resulting in a frameshift and a premature stop codon shortly thereafter. (J:338078)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
