A single loxP site was inserted upstream of exon 2 and an frt-flanked neomycin selection cassette and second loxP site were inserted downstream of exon 4. The neomycin selection cassette was removed via FLP-mediated recombination in the germline. (J:261043)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count