Exons 4-8 were surrounded by loxP sites. A neomycin selection cassette was inserted as well. The loxP -flanked region and the neomycin selection cassette were removed in the germline via Cre-mediated recombination. (J:151923)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count