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Exons 4 and 5 are flanked by loxP sites, and a positive selection marker (Puromycin resistance) flanked by frt sites was inserted into intron 5, then subsequently removed via FLP-mediated recombination in the germline. Further Cre-mediated recombination in the germline resulted in the deletion of exons 4 and 5. (J:268644)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
