Exons 4 and 5 are flanked by loxP sites, and a positive selection marker (Puromycin resistance) flanked by frt sites was inserted into intron 5, then subsequently removed via FLP-mediated recombination in the germline. (J:268644)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count