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CRISPR/cas9 endonuclease-mediated genome editing is used to insert a loxP-flanked SA-F-neo-STOP sequence in intron 3, followed by an arginine to tryptophan amino acid substitution at codon 201 (R201W, CGA to TGG and silent ACT to ACC mutation in codon 202) in exon 4 of the gene. The mutation is orthologous to the human R203W mutation. (J:338950)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
