LoxP sites flank exon 4 and an frt-flanked lacZ gene and neomycin selection cassette is inserted into intron 3. A knockout first conditional-ready targeting construct designed by EUCOMM was used for targeting. (J:299029)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count