LoxP sites and an frt-flanked neomycin selection cassette were inserted to flank exons 2 and 3. FLP-mediated recombination in the germline resulted in the removal of the neomycin cassette, leaving the loxP sites flanking exons 2 and 3. (J:280768)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count