A flippase recombinase target (FRT)-flanked region containing the LacZ beta-Galactosidase and Neomycin expression genes and a LoxP-flanked region containing exons 4 and 5 was inserted into the gene. The LacZ beta-Galactosidase and Neomycin cassettes were removed via Flp-mediated recombination in the germline, leaving loxP sites flanking exons 4 and 5. (J:240623)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count