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Using CRISPR/Cas9 technology, a a nuclear localization sequence (NLS) followed by a codon optimized Cre recombinase fused to ERT2, a GSG linker and a P2A peptide (for production of a bicistronic mRNA transcript) immediately was inserted into the endogenous Myh11 gene immediately after the first codon ATG in exon 2. Cre expression is constitutive rather than inducible by tamoxifen. (J:338442)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
