Csrp3^tm1.1Kage

The targeting vector used to create the Csrp3tm1a(EUCOMM)Hmguallele was modified with a T-to-G mutation to change cysteine codon 58 (TGT) in exon 3 to glycine (GGT) (p.C58G). Founder mice created after homologous recombination with this modified vector were crossed with Flpe expressing mice, resulting in the removal of the FRT site flanked lacZ and neomycin resistance gene cassettes inserted into intron 2. The resulting allele contains single FRT and loxP sites in intron 2 and an exon 3 with the p.C58G mutation. The mutation mimics the same human mutation associated with hypertrophic cardiomyopathy (HCM). (J:307893)